Low Notch-1 and High Jagged-1 Expressions are Associated with Better Treatment Response and Survival in Adult Egyptian Patients with Acute Myeloid Leukemia

Background: Acute Myeloid Leukemias (AMLs) are neoplastic proliferations arising in hematopoietic precursor cells the bone marrow resulting overgrowth of myeloblasts and other myeloid lineage. Notch-1 receptor is a transmembrane protein type I. Interactions between its ligands Jagged-1 Dll-1 result proteolytic cleavages inside receptor, followed by release nuclear translocation intracellular domain (Notch-1-IC). expression was also found CD34+ progenitors peripheral blood marrow. Delta-like1 (Dll-1) seem to be functionally opposing members ligand family; however, their precise methods action AML unknown.
 Methods: Using flow cytometry, surface on leukemic blasts from newly diagnosed patients evaluated. In addition, associated with clinical data, laboratory responsiveness therapy, Disease-Free (DFS) Overall Survival (OS).
 Results: positively expressed 20% studied patients. Positive shorter OS (6.1 months) DFS (3.1 months). Higher levels were significantly lower remission higher relapse rates. contrary, marker weas 56% patients, those showed (6.6 longer (3.6 compared negatively ones. recorded 30 % yet no significant relationship rates as well outcome after therapy.
 Conclusion: Both ligands, Dll-1, implicated pathogenesis, however has greater impact findings than Dll-1. A better prognosis related high individuals AML. Hence, further research required acquire knowledge modes